Conventional antibodies and their derived fragments are difficult to deploy against intracellular targets in live cells, due to their bulk and structural complexity.Nanobodies provide an alternative modality, with well-documented examples of intracellular expression.Despite their promise as intracellular reagents, there has not been a systematic st
Modeling cell biological features of meiotic chromosome pairing to study interlock resolution.
During meiosis, homologous chromosomes become associated side by side in a process known as homologous chromosome pairing.Pairing requires long range chromosome motion through a nucleus that is full of other chromosomes.It remains unclear how the cell manages to align each pair of chromosomes quickly while mitigating and resolving interlocks.Here,
Phenotypic Dimensions of Spirituality: Implications for Mental Health in China, India, and the United States
While the field of empirical study on religion and spirituality in relation to mental health has rapidly expanded over the past decade, little is known about underlying dimensions of spirituality cross-culturally conceived.We aimed to SWIMWEAR bridge this gap by inductively deriving potential universal dimensions of spirituality through a large-sca